Examining Transcriptomic Differences Underlying Mycosis Fungoides in Skin of Color and White Patients

Abstract Mycosis Fungoides (MF), the most common type of cutaneous T-cell lymphoma, typically presents with an erythematous or dyspigmented rash that can progress to tumors and ulcerations on skin. MF is more in skin color (SOC) patients, where it earlier at a higher T-stage. This has led poorer prognosis SOC poorest African Americans. The pathogenesis regarding this racial disparity remains poorly understood. We compared samples from White patients determine differentially expressed genes elucidate transcriptomic differences. An immune panel 343 were hybridized 8 samples. resulting gene signatures analyzed significant genes. Analysis revealed downregulation critical response involved recruitment cells sites inflammation, including CCR1, CCR2, CCR3. Genes ‘chemokine signaling,’ ‘differentiation maintenance myeloid cells,’ ‘cell migration adhesion,’ downregulated biopsies as biopsies. Furthermore, have greater abundance mast cells, whereas neutrophils. These differences suggest may unique involves host’s response. potentially provides insight into presentation advanced stage aggressive course facilitate development immunotherapies targeted address disparity. SD - recipient Dermatology Foundation DRSA; JMR Skin Color Society Reseach Grant; ASB American Association Milstein Research Scholar Award for Melanoma/Non-Melanoma Cancer